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1.
Acta méd. colomb ; 48(3)sept. 2023.
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1549991

RESUMO

Objetives: to evaluate the benefit of implementing 18F-FDG PET/TC in the staging and treatment adjustment of patients with sarcoidosis, compared with the signs and symptoms and complementary test results usually employed. Materials and methods: an observational, analytical electronic chart review of a retrospective cohort of patients seen for sarcoidosis in the internal medicine department of a Spanish university hospital. Results: a total of 31 patients (18 males) were evaluated, with an average age of 54.6±14.71 years and 11±5.75 years since their sarcoidosis diagnosis. In the 84.6% of the reviews, positive uptake was objectified on the 18F-FDG PET/TC. In the 42.3% of the occasions, the objectified find ing allowed restaging of the patient. The 18F-FDG PET/TC result justified the choice of treatment in the 71% of the reviews. Conclusions: 18F-FDG PET/TC provided additional advantages in the staging and therapeutic management of patients with sarcoidosis, compared with the evaluation of signs and symptoms and other clinical tests usually employed in follow up, due to its greater accuracy in determining the activity and extension of the disease. (Acta Med Colomb 2022; 48. DOI: https://doi.org/10.36104/amc.2023.2778).

2.
Gac Med Mex ; 158(5): 271-282, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36572020

RESUMO

OBJECTIVES: To determine weight, height and body mass index (BMI) of schoolchildren from the La Mancha-Centro health area and compare them with those determined by the Spanish Cross-sectional Growth Study 2010 (SCGS-2010). METHODS: Cross-sectional study of 954 schoolchildren aged 6-12 years. Mean, standard deviation, and percentile distributions of weight, height, and BMI by gender and age were obtained. Differences in each 6-month age group were analyzed. RESULTS: There was a progressive increase in BMI with age, which was significant in girls from nine years of age on and in boys from 8.5 years on. From age 10, average BMI was 2.3 kg/m2 higher than at younger ages (p < 0.001). The biggest difference between genders occurred at age 12: 2 ± 0.98 kg/m2 higher in boys (p = 0.042). Overall, no significant differences were found in weight, height and BMI vs. SCGS-2010, although mean weight of male children from La Mancha-Centro aged between 8.5 and 11.5 years was 3.9 kg higher than that of the rest of Spanish male children. CONCLUSIONS: Anthropometric parameters of schoolchildren from La Mancha-Centro do not significantly differ from national standards; however, preadolescent males from La Mancha-Centro weigh almost 4 kg more.


OBJETIVOS: Determinar peso, talla e índice de masa corporal (IMC) de escolares del área de salud La Mancha-Centro y compararlos con los definidos en el Estudio Transversal Español de Crecimiento 2010 (ETEC-2010). MÉTODOS: Estudio transversal de 954 escolares entre 6 y 12 años. Se obtuvieron media, desviación estándar y distribuciones percentilares de peso, talla e IMC por sexo y edad. Se analizaron las diferencias en cada grupo semestral de edad. RESULTADOS: Existió incremento progresivo del IMC con la edad, significativo en las niñas a partir de los nueve años y en los niños desde los 8.5 años. Desde los 10 años, el IMC promedio resultó 2.3 kg/m2 superior al de edades menores (p < 0.001); la mayor diferencia entre los sexos ocurrió a los 12 años: 2 ± 0.98 kg/m2 más en los varones (p = 0.042). Globalmente no se hallaron diferencias significativas de peso, talla e IMC con el ETEC-2010, aunque el peso medio de los niños manchegos de 8.5 a 11.5 años fue 3.9 kg mayor que el del resto de los niños españoles. CONCLUSIONES: Los parámetros antropométricos de los escolares manchegos no difieren de los estándares nacionales; sin embargo, los varones preadolescentes manchegos pesan casi 4 kg más.


Assuntos
Estudos Transversais , Criança , Humanos , Masculino , Feminino , Lactente , Antropometria , Índice de Massa Corporal
4.
Gac. méd. Méx ; 158(5): 281-292, sep.-oct. 2022. tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1404856

RESUMO

Resumen Objetivos: Determinar peso, talla e índice de masa corporal (IMC) de escolares del área de salud La Mancha-Centro y compararlos con los definidos en el Estudio Transversal Español de Crecimiento 2010 (ETEC-2010). Métodos: Estudio transversal de 954 escolares entre 6 y 12 años. Se obtuvieron media, desviación estándar y distribuciones percentilares de peso, talla e IMC por sexo y edad. Se analizaron las diferencias en cada grupo semestral de edad. Resultados: Existió incremento progresivo del IMC con la edad, significativo en las niñas a partir de los nueve años y en los niños desde los 8.5 años. Desde los 10 años, el IMC promedio resultó 2.3 kg/m2 superior al de edades menores (p < 0.001); la mayor diferencia entre los sexos ocurrió a los 12 años: 2 ± 0.98 kg/m2 más en los varones (p = 0.042). Globalmente no se hallaron diferencias significativas de peso, talla e IMC con el ETEC-2010, aunque el peso medio de los niños manchegos de 8.5 a 11.5 años fue 3.9 kg mayor que el del resto de los niños españoles. Conclusiones: Los parámetros antropométricos de los escolares manchegos no difieren de los estándares nacionales; sin embargo, los varones preadolescentes manchegos pesan casi 4 kg más.


Abstract Objectives: To determine weight, height and body mass index (BMI) of schoolchildren from the La Mancha-Centro health area and compare them with those determined by the Spanish Cross-sectional Growth Study 2010 (SCGS-2010). Methods: Cross-sectional study of 954 schoolchildren aged 6-12 years. Mean, standard deviation, and percentile distributions of weight, height, and BMI by gender and age were obtained. Differences in each 6-month age group were analyzed. Results: There was a progressive increase in BMI with age, which was significant in girls from nine years of age on and in boys from 8.5 years on. From age 10, average BMI was 2.3 kg/m2 higher than at younger ages (p < 0.001). The biggest difference between genders occurred at age 12: 2 ± 0.98 kg/m2 higher in boys (p = 0.042). Overall, no significant differences were found in weight, height and BMI vs. SCGS-2010, although mean weight of male children from La Mancha-Centro aged between 8.5 and 11.5 years was 3.9 kg higher than that of the rest of Spanish male children. Conclusions: Anthropometric parameters of schoolchildren from La Mancha-Centro do not significantly differ from national standards; however, preadolescent males from La Mancha-Centro weigh almost 4 kg more.

5.
Med. clín. soc ; 6(1)abr. 2022.
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1386246

RESUMO

RESUMEN Introducción: un evento adverso es un incidente que ha producido daño en un paciente y que puede o no estar asociado a un error clínico. Un porcentaje elevado de profesionales de la salud se encuentran implicados en este tipo de eventos anualmente. Gran parte de los profesionales desconocen la existencia de los sistemas implantados en sus centros de trabajo para una comunicación correcta de los eventos adversos. Objetivos: identificar las características de los profesionales hospitalarios afectados por algún evento adverso y evaluar su conocimiento de los sistemas de notificación. Metodología: estudio observacional descriptivo transversal. Se evaluaron variables demográficas, laborales y relacionadas con los eventos adversos y los sistemas de notificación. Resultados: participaron 207, 45,4 % enfermeros y 54,6 % médicos, de 39,24 ± 10,07 años y con una experiencia de 14,43 ± 9,9 años. El 71,8 % resultaron afectados por algún evento adverso. El primer evento adverso ocurrió a los 6,45 ± 6,18 años. El 42,1 % conocía algún sistema de notificación; pero sólo el 24,61% de éstos, afectados por un evento adverso, lo notificaron. Los médicos fueron más afectados por un evento adverso, además, más precozmente (p < 0,001); y también conocían los sistemas de notificación (p= 0,001). Conclusión: muchos sanitarios, con escasa experiencia, fueron afectados por eventos adversos. Pocos conocían los sistemas de notificación y muchos menos los utilizaban. Los médicos resultaron más afectados, y más precozmente, por los eventos adversos y conocían mejor los sistemas de notificación.


ABSTRACT Introduction: an adverse event is an incident that has caused harm to a patient and that may or may not be associated with a clinical error. A high percentage of health professionals are involved in this type of event annually. A large part of the professionals are unaware of the existence of the systems implemented in their work centers for a correct communication of adverse events. Objective: to identify the characteristics of hospital professionals affected by an adverse event and to evaluate their knowledge of the notification systems. Methods: cross-sectional descriptive observation-al study. Demographic, labor and related variables with adverse events and notification systems were evaluated. Results: 207, 45.4% nurses and 54.6% doctors, participated, 39.24 ± 10.07 years and with an experience of 14.43 ± 9.9 years. 71.8% were affected by some adverse event. The first adverse event occurred at 6.45 ± 6.18 years. 42.1% knew of some notification system; but only 24.61% of these, affected by an adverse event, report-ed it. Physicians were more affected by an adverse event, moreover earlier (p <0.001) and they were also more aware of notification systems (p = 0.001). Conclusions: many health workers, with little experience, were affected by adverse events. Few knew notification systems and far fewer used them. Doctors were more affected, and earlier, by adverse events and were better acquainted with notification systems.

6.
Nutr. clín. diet. hosp ; 42(1): 169-174, Abr. 2022. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-204604

RESUMO

Introducción: La anorexia nerviosa cursa, excepcionalmente, con un fallo hepático grave debido a una activaciónexcesiva de un proceso de autofagia. Objetivo: Describir los hallazgos clínicos y los resultadosde las exploraciones complementarias más característicos enesta complicación hepática. Material y métodos: Estudio retrospectivo, de diversasvariables clínicas y de exploraciones complementarias, de unaserie de pacientes con anorexia nerviosa que desarrollaronuna hepatopatía aguda asociada a una restricción dietética intensa. Resultados: Se evaluaron 11 episodios de hepatopatíaaguda que sufrieron 8 pacientes de 31,75±7,83 años (una paciente sufrió 4). El índice de masa corporal en el momento dela complicación hepática fue de 12,60± 2,08 kg/m2. Las concentraciones elevadas de AST y ALT fue el rasgo más característico (AST 780,77 ± 553,47 UI/L; ALT 659,2 ± 558,64UI/L). En algunos casos, además, se asociaron hipoglucemia, coagulopatía y/o trombopenia. Se produjo una recuperaciónad integrum de todas las pacientes, en 43,28 ± 15,93 días,tras recibir un tratamiento dietético adecuado (una dieta inicial de 650 ± 154,11 kcal/día, con incremento progresivo deaporte calórico). Discusión: La serie de casos de hepatopatía aguda en pacientes con anorexia nerviosa que se describen, presentabancaracterísticas clínicas comunes a otras similares en las que eldiagnóstico final fue el de autofagia hepática.Conclusión: La autofagia hepática actúa como el mecanismo patogénico de una hepatitis severa reversible en pacientes con anorexia nerviosa grave cronificada.(AU)


Introduction: Exceptionally, anorexia nervosa causes severe liver failure due to excessive activation of autophagy.Objetive: To describe the clinical findings and the resultsof the most characteristic complementary examinations in thishepatic complication. Material and methods: Retrospective study of severalclinical variables and complementary tests of a series of patients with anorexia nervosa who developed acute hepatopathy associated with severe dietary restriction. Results:We evaluated 11 episodes of acute liver diseasesuffered by 8 patients aged 31.75±7.83 years (one patientsuffered 4), The body mass index at the time of the liver complication was 12.60±2.08 kg/m2. Elevated AST and ALT concentrations was the most characteristic feature (AST780.77±553.47 IU/L; ALT 659.2±558.64 IU/L). In somecases, also hypoglycaemia, coagulopathy and/or thrombopenia were associated. All patients recovered ad integrum in43.28 ± 15.93 days after receiving adequate dietary treatment (an initial diet of 650 ± 154.11 kcal/day, with a progressive increase in caloric intake). Discussion: The series of cases of acute liver disease inpatients with anorexia nervosa that are described, presentedclinical characteristics common to other similar ones in whichthe final diagnosis was hepatic autophagy. Conclusion: Liver autophagy is the main pathogenicmechanism of severe reversible hepatitis in patients withchronic severe anorexia nervosa.(AU)


Assuntos
Humanos , Autofagia , Anorexia Nervosa , Falência Hepática , Estudos Retrospectivos , Hipoglicemia , Transtornos da Coagulação Sanguínea , Trombocitopenia , 52503 , Serviço Hospitalar de Nutrição , Análise de Alimentos
7.
Cuad Bioet ; 31(103): 423-427, 2020.
Artigo em Espanhol | MEDLINE | ID: mdl-33375807

RESUMO

The interaction between doctors and pharmaceutical companies has been and is common, occurs in multiple ways and has proven, in many cases, to be necessary for the development of medicine. However, some of the sales techniques of the pharmaceutical industry are not ethically acceptable and can compromise the independence of physicians. An ethical dilemma arises from a real case in which the search for vulnerability in prescription based on a donation by a pharmaceutical company was not easy to identify.


Assuntos
Indústria Farmacêutica/ética , Doações/ética , Marketing/ética , Médicos/ética , Autonomia Profissional , Financiamento de Capital/ética , Crime , Indústria Farmacêutica/legislação & jurisprudência , Endocrinologia , Departamentos Hospitalares , Hospitais Gerais , Hospitais Universitários , Humanos , Marketing/legislação & jurisprudência , Ciências da Nutrição , Equipe de Assistência ao Paciente/economia , Equipe de Assistência ao Paciente/organização & administração , Comunicação Persuasiva , Padrões de Prática Médica/ética
8.
Med. clín. soc ; 4(3)dic. 2020.
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1386200

RESUMO

RESUMEN Introducción: La disfagia tiene una morbimortalidad importante en pacientes hospitalizados. Objetivos: principal; describir las características de los pacientes con disfagia hospitalizados y, secundarios; cuantificar y analizar la prevalencia de mortalidad y de reingresos. Metodología: Estudio transversal descriptivo de las hospitalizaciones por disfagia durante el año 2015 en un Hospital General Universitario. Resultados: Se evaluaron 431 historias clínicas. La edad de los pacientes fue de 83,21 (DE 11,4) años, el 52,5% fueron mujeres y el 47,2% varones; la estancia media fue de 11,1 (DE 7,99) días. En el 71,2 % de los casos la disfagia fue por afectación de la fase orofaríngea. En el 80,51% de los casos se diagnosticaron complicaciones respiratorias: 48,12% neumonía aspirativa por líquidos, 40,05 % neumonitis química por aspiración y 11,81% neumonía aspirativa por sólidos. La mortalidad general asociada a las complicaciones respiratorias respecto del total de los casos de disfagia fue del 24,49%. El 50,48% de los pacientes con neumonía aspirativa fallecieron. La principal causa de la disfagia fue las enfermedades neurológicas (un 77,25%). La mortalidad fue significativamente mayor en las mujeres - 42,3% frente al 7,8% - (p < 0,01) y esta diferencia se mantuvo tras ajustar el resultado por edad: OR 9,937, IC95%: 5,446; 18,131. El 13,10% de los pacientes reingresaron al menos en una ocasión. Los pacientes de geriatría presentaron un mayor número de reingresos por número de ingresos. Discusión: las enfermedades neurológicas fueron la principal causa de disfagia. La mortalidad fue significativamente mayor en las mujeres.


ABSTRACT Introduction: Dysphagia is an important associated morbidity and mortality in hospitalized patient. Objectives: Main; to describe the characteristics of patients admitted for dysphagia and secondary; quantify and analyze the prevalence of mortality and readmissions. Methodology: Cross-sectional study descriptive revenues by dysphagia during the year 2015 in a University General Hospital. Results: 431 records were evaluated. The age of the patients was 83,21 (11.4), 52.5% women and 47.2% male; the average stay was 11.1 (7.99) days. In 71,2% of cases the dysphagia was involvement of the oropharyngeal phase. 80.51% of cases were diagnosed respiratory complications. The percentage distribution of these complications were: in 48.12% aspiration pneumonia due to fluids, in 40.05% chemical aspiration pneumonitis and in 11.81% aspiration pneumonia due to solids. The overall mortality associated with respiratory complications compared to the total of cases of dysphagia was 24.49%. 50.48% of patients diagnosed with aspiration pneumonia died. The main cause of dysphagia was neurological diseases (77.25%). Mortality was significantly higher in women - 42.3% of women compared with 7.8% of males - (p < 0.01) and this difference remained after adjusting the result by age: OR 9,937, 95% CI: 5,446; 18,131. 13.10% of patients re-entered at least on one occasion. Patients of geriatric unit that presented in greater number of readmissions by admissions. Discussion: neurological diseases were the main cause of dysphagia. Mortality was significantly higher in women

9.
Cuad. bioét ; 31(103): 423-427, sept.-dic. 2020.
Artigo em Espanhol | IBECS | ID: ibc-200031

RESUMO

La interacción entre los médicos y las compañías farmacéuticas ha sido y es habitual, se produce de múltiples formas y ha demostrado, en muchos casos, ser necesaria para el desarrollo de la medicina. Sin embargo, algunas de las técnicas de venta de la industria farmacéutica no son éticamente admisibles y pueden comprometer la independencia de los médicos. Se plantea un dilema ético a partir de un caso real en el que la búsqueda de la vulnerabilidad en la prescripción a partir de una donación por parte de una compañía farmacéutica no fue fácil de identificar


The interaction between doctors and pharmaceutical companies has been and is common, occurs in multiple ways and has proven, in many cases, to be necessary for the development of medicine. However, some of the sales techniques of the pharmaceutical industry are not ethically acceptable and can compromise the independence of physicians. An ethical dilemma arises from a real case in which the search for vulnerability in prescription based on a donation by a pharmaceutical company was not easy to identify


Assuntos
Humanos , Doações/ética , Indústria Farmacêutica/ética , Prescrições de Medicamentos , Ética Médica , Publicidade de Medicamentos , Conflito de Interesses , Médicos/ética , Instalações de Saúde/ética
13.
Endocrinol. nutr. (Ed. impr.) ; 57(6): 240-244, jul. 2010. tab
Artigo em Espanhol | IBECS | ID: ibc-87423

RESUMO

Objetivo Evaluar el rendimiento diagnóstico de los hallazgos ecográficos (tamaño nodular, existencia de microcalcificaciones y ecogenicidad) en relación con el resultado de las citologías tiroideas obtenidas por punción aspiración con aguja fina. Metodología Fueron analizados los resultados de las citologías y las características ecográficas de 341 nódulos tiroideos. Resultados El 25,5% de las citologías fueron insuficientes, el 65,1% benignas y el 7,9% sospechosas y malignas. El porcentaje de muestras insuficientes fue claramente mayor en los nódulos menores de 15mm, pero también fue mayor el de citologías malignas entre este grupo de menor tamaño (11,1 frente al 2,8%; p=0,04). Entre los menores de 10mm, el porcentaje de muestras insuficientes se elevó hasta el 66,7% y no se detectó ninguna maligna. Destacó la ausencia de citologías sospechosas o malignas en los nódulos hiperecoicos y los anecoicos. La hipoecogenicidad fue, por el contrario, el rasgo de ecogenicidad que se asoció más frecuentemente con malignidad. Aunque la ecogenicidad en su conjunto no se asoció significativamente con la malignidad (p=0,313). La mayoría (6 de 10) de los casos con microcalcificaciones tuvo diagnóstico de malignidad frente a 4 de los 239 casos (1,7%) sin calcificaciones (p<0,001). En un modelo multivariante de regresión logística, la única variable que retuvo la significación estadística en su relación con la malignidad de la citología fue la presencia de microcalcificaciones. Conclusiones La citología tiroidea es un método eficaz para evaluar los nódulos tiroideos mayores de 10mm. La presencia de microcalcificaciones intranodulares se asocia significativamente con malignidad, mientras que la hiperecogenicidad y la anecogenicidad lo hacen con benignidad (AU)


Objetive To evaluate the diagnostic efficiency of sonographic findings (nodule size, the presence of microcalcifications and echogenicity) compared with the results of fine-needle aspiration biopsy (FNAB) of thyroid nodules. Methods The results of cytology and the ultrasound characteristics of 341 thyroid nodules were analyzed. Results A total of 25.5% of the FNAB were inadequate, 65.1% were benign and 7.9% were suspicious or malignant. The percentage of inadequate samples was clearly larger in nodules smaller that 15 mm but that of malignant cytologies was also larger in this group of nodules (11.1 versus 2.8%: p=0.04). The percentage of inadequate samples among nodules smaller than 10 mm was 66.7% and no malignancies were detected. A notable finding was the absence of suspicious or malignant FNAB in hyperechogenic and anechogenic nodules. In contrast, the echogenic feature most frequently associated with malignancy was hypoechogenicity, although echogenicity, as a whole, was not significantly associated with malignancy (p=0.313). Most cases with microcalcifications (6 of 10) were malignant compared with four of the 239 nodules (1.7%) without calcifications (p<0.001). Multivariate logistic regression revealed that the only variable maintaining a significant association with malignancy was the presence of microcalcifications. Conclusions Thyroid cytology is an efficient method to evaluate thyroid nodules larger than 10mm. The presence of nodule microcalcifications is significantly associated with malignancy, while hyperechogenicity and anechogenicity are associated with benign nodules (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Nódulo da Glândula Tireoide/patologia , Nódulo da Glândula Tireoide , Neoplasias da Glândula Tireoide/patologia , Neoplasias da Glândula Tireoide , Biópsia por Agulha , Estudos Transversais
15.
Endocrinol Nutr ; 57(6): 240-4, 2010.
Artigo em Espanhol | MEDLINE | ID: mdl-20447882

RESUMO

OBJECTIVE: To evaluate the diagnostic efficiency of sonographic findings (nodule size, the presence of microcalcifications and echogenicity) compared with the results of fine-needle aspiration biopsy (FNAB) of thyroid nodules. METHODS: The results of cytology and the ultrasound characteristics of 341 thyroid nodules were analyzed. RESULTS: A total of 25.5% of the FNAB were inadequate, 65.1% were benign and 7.9% were suspicious or malignant. The percentage of inadequate samples was clearly larger in nodules smaller that 15 mm but that of malignant cytologies was also larger in this group of nodules (11.1 versus 2.8%: p=0.04). The percentage of inadequate samples among nodules smaller than 10 mm was 66.7% and no malignancies were detected. A notable finding was the absence of suspicious or malignant FNAB in hyperechogenic and anechogenic nodules. In contrast, the echogenic feature most frequently associated with malignancy was hypoechogenicity, although echogenicity, as a whole, was not significantly associated with malignancy (p=0.313). Most cases with microcalcifications (6 of 10) were malignant compared with four of the 239 nodules (1.7%) without calcifications (p<0.001). Multivariate logistic regression revealed that the only variable maintaining a significant association with malignancy was the presence of microcalcifications. CONCLUSIONS: Thyroid cytology is an efficient method to evaluate thyroid nodules larger than 10 mm. The presence of nodule microcalcifications is significantly associated with malignancy, while hyperechogenicity and anechogenicity are associated with benign nodules.


Assuntos
Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/patologia , Nódulo da Glândula Tireoide/diagnóstico por imagem , Nódulo da Glândula Tireoide/patologia , Biópsia por Agulha , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ultrassonografia
18.
Endocrinol Nutr ; 56(5): 273-6, 2009 May.
Artigo em Espanhol | MEDLINE | ID: mdl-19627750

RESUMO

We present 4 patients with Graves' disease who developed spontaneous hypothyroidism during follow-up. The two most plausible physiopathologic mechanisms for this development were progressive autoimmune-mediated destruction of the thyroid follicular epithelium and a predominance of blocking antibodies to the thyroid-stimulating hormone (TSH) receptor at the expense of stimulating antibodies in the same patient. Description of these patients not only illustrates the heterogeneous nature of this disease, but also the interrelation among its distinct clinical forms.


Assuntos
Doença de Graves/complicações , Hipotireoidismo/etiologia , Adulto , Idoso , Autoanticorpos/sangue , Autoanticorpos/imunologia , Progressão da Doença , Feminino , Bócio/etiologia , Doença de Graves/sangue , Doença de Graves/tratamento farmacológico , Doença de Graves/imunologia , Doença de Graves/fisiopatologia , Humanos , Hipotireoidismo/sangue , Hipotireoidismo/tratamento farmacológico , Hipotireoidismo/imunologia , Hipotireoidismo/fisiopatologia , Imunoglobulinas Estimuladoras da Glândula Tireoide/sangue , Imunoglobulinas Estimuladoras da Glândula Tireoide/imunologia , Masculino , Metimazol/uso terapêutico , Pessoa de Meia-Idade , Receptores da Tireotropina/imunologia , Hormônios Tireóideos/sangue , Tireotoxicose/etiologia , Tiroxina/uso terapêutico
19.
Endocrinol. nutr. (Ed. impr.) ; 56(5): 273-276, mayo 2009. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-61723

RESUMO

Presentamos los casos de 4 pacientes con enfermedad de Graves- Basedow que, durante el curso de su proceso patológico, sufrieron hipotiroidismo espontáneo. Los dos mecanismos fisiopatológicos más probables para explicar esta evolución son la destrucción autoinmunitaria progresiva del epitelio folicular tiroideo y la predominancia de anticuerpos inhibidores de los receptores de tirotropina (TSH) frente a anticuerpos estimulantes en un mismo paciente con enfermedad de Graves-Basedow. La exposición de estos 4 casos ilustra la heterogeneidad de esta enfermedad, así como la interrelación de las distintas formas clínicas de la enfermedad tiroidea autoinmunitaria (AU)


We present 4 patients with Graves’ disease who developed spontaneous hypothyroidism during follow-up. The two most plausible physiopathologic mechanisms for this development were progressive autoimmune-mediated destruction of the thyroid follicular epithelium and a predominance of blocking antibodies to the thyroidstimulating hormone (TSH) receptor at the expense of stimulating antibodies in the same patient. Description of these patients not only illustrates the heterogeneous nature of this disease, but also the interrelation among its distinct clinical forms (AU)


Assuntos
Humanos , Hipotireoidismo/complicações , Doença de Graves/complicações , Receptores da Tireotropina/antagonistas & inibidores , Tireoidite Autoimune/metabolismo , Testes de Função Tireóidea
20.
Endocrinol. nutr. (Ed. impr.) ; 55(7): 301-303, ago. 2008. ilus
Artigo em Es | IBECS | ID: ibc-69980

RESUMO

Presentamos el caso de una paciente de 62 años con nódulo parasitariode tiroides y tiroiditis crónica de Hashimoto. La paciente se sometió a una hemitiroidectomía derecha por un nódulo de 15 mm con sospecha citológica de malignidad. Durante el acto quirúrgico se identificó un ganglio recurrencial ipsolateral que fue extirpado. El estudio anatomopatológico posterior estableció que no se trataba de un gangliolinfático, sino de un nódulo tiroideo extracapsular (nódulo parasitario) (AU)


We present a case of parasitic thyroid nodule in a 62-year-old woman with Hashimoto’s thyroiditis. The patient underwent right hemithyroidectomy for a15-mm nodule suspicious for malignancy. A recurrential ipsilateral lymph nodule was identified and removed. Conclusive histopathologic study confirmed that the mass was an extracapsular thyroid nodule (parasitic nodule) (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Nódulo da Glândula Tireoide/etiologia , Tireoidite Autoimune/complicações , Bócio Nodular/complicações , Tireoidectomia , Glândula Tireoide/anormalidades
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